5-HT                                       BUFO                                     TRYP

 

 

 

 

The above ligands show the molecular electrostatic potentials (MEPs)(negative regions are colored red and positive regions are colored blue) of the ligands 5-HT (serotonin), BUFO (bufotenin) and TRYP (tryptamine) molecules not docked into the 5HT2A receptor. The molecules below are the MEPs of these ligands docked with the 5HT2A receptor in the acid (SH) state (see this link for the receptor model and this link for the paper):

 

 

5-HT                                       BUFO                                     TRYP

 

 

 

 

 

The same ligands as above, but docked with the 5HT2A receptor in the base (S-) state:

 

 

5-HT                                       BUFO                                     TRYP

 

 

 

 

 

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